Despite the turbulent years of the World War II (1941-1945), the Kindergarten and the Grade School continued in operation. It was in 1942 when the girl’s high school reopened to allow the senior students to graduate. Rapid development marked the years during the Liberation Period. Religion has become the core of the curriculum fostering virtues, graces, and high regard for family life. Spiritual, moral, and intellectual growth has become its focus. A coeducational setup was introduced by Fr. Pastor Ybañez.
In May 1976, the Congregacion de las Religiosas Misioneras de Santo Domingo (CRMSD) took over the management of the school upon the invitation of His Eminence Julio Cardinal Rosales. In 1993, St. Catherine’s School opened higher education department offering Bachelor in Elementary Education, Bachelor in Secondary Education, and Bachelor of Arts (major in English). Renamed St. Catherine’s College in 1994, it had B.S in Computer Engineering, B.S. in Computer Science, Associate in Computer Science, Associate in Computer Secretarial, B.S. in Accountancy, and B.S. in Business Administration as additional programs under the close supervision of the Commission on Higher Education (CHED). On the other hand, the school also offered technical vocational courses in Nursing Aide, General Radio Telecommunications Operator (GRCO), and Electronics Communications Technician (ECT) under the Umbrella of TESDA.